The present project will investigate the uptake and metabolization of rye bioactive constituents in prostate tissue; elucidate the effects of a high and low benzoxazinoid diet on metabolic changes in prostate cancer; correlate between markers, clinic-pathological factors and metabolomics results; conclude on which compounds are active in the suppressive effects on prostate cancer and so provide the reasons for using whole grain rye as adjuvant to the medicinal treatment of prostate cancer.
The RyeproC project (“Whole grain rye as a functional food for suppression of prostate cancer – elucidating the role of benzoxazinoids and other bioactive constituents”) is coordinated by associate professor, PhD Inge S. Fomsgaard, Aarhus University, Dept. of Agroecology.
The research work is distributed in two work packages as listed below (Acronym of participating researcher in parenthesis, bold text: principal).
WP1. Elucidation of chemical structures
Structural elucidation of whole grain rye bioactive constituents in human prostate tissue (IFO, SKS, MIB, MEB), search for specific prostate tissue metabolization products (SKS, IFO), synthesis of identified compounds (SKS, IFO).
WP2. Effect of intake of whole grain rye food products on prostate cancer
Intervention study and sampling of prostate biopsies (MIB, MEB, SØH), elucidation of molecular reactions (SØH, MIB, scholar), metabolic profiling of primary and secondary metabolites (SKS, MIB, IFO), advanced statistical correlation (MIB, SØH, SKS, IFO, MEB).
BREAD AND BREAKFAST (Exploiting newly discovered multiple-effect bioactive compounds for the development of immunoregulatory and appetite-controlling bread and breakfast products)
www.breadandbreakfast.nu
Financed by the Danish Strategic Research Council.
MolPros (Molecular Prediction of Prostate Cancer Risk and Aggressiveness)
www.MOLPROS.DK
Financed by Aarhus University
FATEALLCHEM (Fate and toxicity of allelochemicals (natural plant toxins) in relation to environment and consumer)
www.fateallchem.dk
EU financed FP5 project, on the ecological importance of benzoxazinoids:
AMARANTH:FUTURE-FOOD (Adding Value to Holy Grain: Providing the Key Tools for the Exploitation of Amaranth - the Protein-rich Grain of the Aztecs
www.amaranth-future-food.net
EU financed FP6 project
Aarhus University, Department of Agroecology,
Forsøgsvej 1, DK-4200 Slagelse, Denmark
Associate professor, PhD Inge S. Fomsgaard
inge.fomsgaard@agro.au.dk
87158212 / 22283399
Head Laboratory Technician Bente B. Laursen
benteb.laursen@agro.au.dk
87157503 / 24242956
Administrative case officer Inge Harbo
inge.harbo@au.dk
87157665
Post doc Stine Krogh Steffensen
stinek.steffensen@agro.au.dk
22739836
Clinical nutritionist Mette Borre
mette.borre@aarhus.rm.dk
78462815 / 24625453
Consultant Mette Skaanild
mts@skaanild.dk
21 63 77 70
Aarhus University Hospital, Department of Clinical Medicine - The Department of Urology K
Brendstrupgårdsvej 100, DK-8200 Aarhus N, Denmark
Clinical professor, dr.med Michael Borre
borre@clin.au.dk
78 45 26 16
29 61 27 13
Project Nurse Helene Holm Pedersen
helene.holm@skejby.rm.dk
78 45 26 38
Aarhus University Hospital, Department of Pathology,
Noerrebrogade 44, DK-8000 Aarhus C, Denmark
Head of department, Dr. Søren Høyer
http://www.auh.dk/om-auh/afdelinger/patologisk-institut/kontakt/kontakt-Patologisk-Institut/
soren.hoyer@aarhus.rm.dk
78 46 36 93 / 29 87 18 24
The RyeproC project is funded by The Danish Council for Independent Research – Technology and Production (12-127498).
External support is generously provided by the following companies:
Lantmännen http://lantmannen.se/
Ellegaard Göttingen Minipigs www.minipigs.dk
Cytotrack www.cytotrack.dk
Participants of the RyeproC project are grateful for the funding.
2018
Effects of benzoxazinoids on prostate cancer cells
2017
Bioactive small molecules in commercially available cereal food: Benzoxazinoids
Biphenyl Columns Provide Good Separation of the Glucosides of DIMBOA and DIM(2)BOA
The role of benzoxazinoids, new players for human health
Alterations of the benzoxazinoid profiles of uninjured maize seedlings during freezing, storage, and lyophilization
Effects of plant secondary metabolite benzoxazinoids on the plant microbiome
2016
Benzoxazinoids in Prostate Cancer Patients after a Rye-Intensive Diet: Methods and Initial Results
2015
Benzoxazinoids: Cereal phytochemicals with putative therapeutic and health-protecting properties
2013
Hvorfor kan rug bremse kræft? Videnskab.dk
Rye bread against prostate cancer. DCA - Danish Centre For Food And Agriculture