RyeproC

Whole grain rye as a functional food for suppression of prostate cancer – elucidating the role of benzoxazinoids and other bioactive constituents

Project summary

The present project will investigate the uptake and metabolization of rye bioactive constituents in prostate tissue; elucidate the effects of a high and low benzoxazinoid diet on metabolic changes in prostate cancer; correlate between markers, clinic-pathological factors and metabolomics results; conclude on which compounds are active in the suppressive effects on prostate cancer and so provide the reasons for using whole grain rye as adjuvant to the medicinal treatment of prostate cancer.

Management

The RyeproC project (“Whole grain rye as a functional food for suppression of prostate cancer – elucidating the role of benzoxazinoids and other bioactive constituents”) is coordinated by associate professor, PhD Inge S. Fomsgaard, Aarhus University, Dept. of Agroecology.

The research work is distributed in two work packages as listed below (Acronym of participating researcher in parenthesis, bold text: principal).

WP1. Elucidation of chemical structures

Structural elucidation of whole grain rye bioactive constituents in human prostate tissue (IFO, SKS, MIB, MEB), search for specific prostate tissue metabolization products (SKS, IFO), synthesis of identified compounds (SKS, IFO).

WP2. Effect of intake of whole grain rye food products on prostate cancer
Intervention study and sampling of prostate biopsies (MIB, MEB, SØH), elucidation of molecular reactions (SØH, MIB, scholar), metabolic profiling of primary and secondary metabolites (SKS, MIB, IFO), advanced statistical correlation (MIB, SØH, SKS, IFO, MEB).

Project coordinator

Inge S. Fomsgaard

Professor

M inge.fomsgaard@agro.au.dk

P +4587158212
P +4522283399

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